Furthermore, Mmp28 was found to modulate myelination in the peripheral nervous system and to be upregulated in neurological disease conditions, such as experimental autoimmune encephalitis and multiple sclerosis (Werner et al., 2008), where it may act as a negative regulator of macrophage chemotaxis by mechanisms that are elusive (Gharib et al., 2014). Here, MMP28 is linked to nervous system disorder.