RAN and amyotrophic lateral sclerosis: Regardless, mounting evidence in mice and humans indicates that sporadic and familial ALS promote impairments of multiple components that are dependent on the Ran GTPase cycle (Jovičić et al., 2015; Freibaum et al., 2015; Zhang et al., 2015; Kim et al., 2013; Boeynaems et al., 2016; Xiao et al., 2015a; Zhang et al., 2006; Kinoshita et al., 2009), which controls nucleocytoplasmic trafficking of substrates implicated in ribostasis (Kim et al., 2013; Dickmanns et al., 2015; Cautain et al., 2015).