HNRNPA2B1 and amyotrophic lateral sclerosis: Our prior studies identified the ALS-causing protein, hnRNPA2B1, as a substrate of Ranbp2, and hnRNPA2B1 proteostasis is dependent on the cis-trans prolyl isomerase activity of Ranbp2 (Cho et al., 2015b, 2014).