MYC and hematopoietic and lymphoid system neoplasm: In the original work, Delmore et al. measured gene expression and cell proliferation in vitro (in blood cancer cell lines) before and after treatment with JQ1, and observed that treatment with JQ1 resulted in significant changes in the transcription of many (but not all) of the genes in the c-Myc-related gene transcription network: 88 genes were down-regulated by a factor of two or more, and 25 were up-regulated by a similar factor.