PREX2 and melanoma: While Berger et al. (2012) reported PREX2 as an SMG in melanoma, other studies have failed to identify PREX2 as an SMG in genome-wide screens of melanoma samples (Cancer Genome Atlas Network, 2015; Hodis et al., 2012; Krauthammer et al., 2012; Marzese et al., 2014; Ni et al., 2013), including a meta-analysis of over 200 samples (Xia et al., 2014).