The liposomes were encapsulated with a high concentration of the NIRF dye, DY-676-COOH (excitation /emission: 674 nm /699 nm) and conjugated to single chain antibody fragments (scFv) directed to either fibroblast activation protein (FAP) which is overexpressed on tumor associated fibroblasts of 90% of tumors but not healthy tissues [21], or to endoglin, which is overexpressed on some tumor cells and the majority of tumor neovasculature [22]. This evidence concerns the gene FAP and neoplasm.