For example, TRIM28 functions as a transcriptional corepressor in orchestrating the primer binding site‐mediated silencing of integrated M‐MLV proviruses in mouse embryonic carcinoma and embryonic stem cells (Wolf and Goff, 2007), while TRIM19 (PML) regulates asymmetric division of hematopoietic stem cells via PPAR‐δ‐FAQ pathway (Ito et al., 2012). The gene discussed is PML; the disease is embryonal carcinoma.