Recently, tri‐partite motif‐containing protein 8 (TRIM8) has been shown to interact with PIAS3, either by causing its degradation through the ubiquitin‐proteasome pathway or through its exclusion from the nucleus, resulting in enhanced STAT3‐dependent signaling in a subset of cancer cell lines (Okumura et al., 2010). Here, PIAS3 is linked to cancer.