Previous studies have investigated three common tagging SNPs (rs11801299 G>A and rs1380576 C>G in 3′-untranslated region [3′-UTR] and rs10900598 G>T in 5′-UTR) of the MDM4 gene with risk of oral cancer, squamous cell carcinoma of oropharynx and squamous cell carcinoma of the head and neck and got some positive findings [16–18]. The gene discussed is MDM4; the disease is squamous cell carcinoma.