As cordycepin upregulated CAV1 expression and JNK phosphorylation, and inhibited phosphorylation of Foxo3a in vitro, we next examined CAV1, the phosphorylation status of JNK, total JNK, p-Foxo3a, and total Foxo3a protein in tumor tissues by immunohistochemistry. Here, FOXO3 is linked to neoplasm.