CNP and glioblastoma: We found that all the glioblastoma cell lines but A172 cell line expressed GUCY1A2, GUCY1A3, GUCY1B3, the subunits of the the dimeric soluble GC receptor activated by NO, as well as NPR2, the receptor-coupled GC isoform that binds C-type natriuretic peptide (CNP) (Supplementary Figure 1E).