Similar observation was also reported by Coomans de Brachene and colleagues that the PI3K inhibitor LY294002 or other Akt inhibitor (Akt inhibitor VIII or MK 2206) caused increased mRNA or protein expression of HBP1 in either eosinophilic leukemia or colon carcinoma cells [18]. Here, HBP1 is linked to Chronic Eosinophilic Leukemia, Not Otherwise Specified.