These future challenges will help to determine how the relationship between Fibulin-2 and ADAMTS metalloproteases could also influence the tumor-protective role associated to Fibulin-2 in other types of tumors such as nasopharyngeal carcinomas [11]; or the tumor-promoting functions of Fibulin-2 in lung cancer [10]. This evidence concerns the gene FBLN2 and nasopharyngeal carcinoma.