We performed an immunohistochemical analysis of the expression of ADAMTS-5 and Fibulin-2 in a tissue array containing 48 invasive ductal carcinoma (IDC) tissue samples from different differentiation grades (14 samples IDC grade I, IDC-I; 6 grade I–II; 6 grade II; 4 grade II–III; and 18 grade III), as IDC is the most common type of breast cancer. This evidence concerns the gene ADAMTS5 and invasive ductal breast carcinoma.