To elucidate whether endogenous Fibulin-2 could also be degraded by these proteases, we carried out transfections only with plasmids containing the full-length cDNA for ADAMTS-4 or ADAMTS-5 into SK-BR-3 breast cancer cells, which endogenously express Fibulin-2 [12]. This evidence concerns the gene FBLN2 and breast carcinoma.