CD274 and neoplasm: ∙ Inhibition of dendritic cell differentiation and function∙ Cytotoxicity to macrophages, neutrophils, and eosinophils∙ Induction of apoptosis in proliferating B cells∙ Increased tumor killing by NK cells and cytotoxic T cells∙ Increased differentiation and function of CD8+ T cells∙ Inhibition immunosuppressive functions of regulatory T cells∙ Suppression of inflammatory cytokine production∙ Increased expression of PD-L1