LEPR and Mental deterioration: To elucidate the role of ZBPYR in regulating the balance of gut microbiota affecting psychological-stress-induced diabetes-associated cognitive decline (PSDACD), we used male Zuker diabetes fatty (ZDF) rat as T2D model, which presents developing hyperinsulinemia and hyperglycaemia [23] and is initiated with a mutation in the leptin receptor gene [24, 25].