In bladder cancer, Twist1 regulates Y-box-binding protein-1 (YB1) expression and both Twist1 and YB1 are involved in cell growth, invasion, motility, and resistance to cisplatin and doxorubicin, but not to 5-fluorouracil (5-FU) [112]. This evidence concerns the gene TWIST1 and urinary bladder carcinoma.