In the current study, we determined both the mRNA and protein expression of PHD1–3 and FIH in HCC tissue samples by RT-PCR, tissue microarray (TMA) immunohistochemistry (IHC) analysis and western blotting assay, and correlated the different expression levels of these hydroxylases to the clinical and histoprognostic characteristics and prognosis of HCC patients. Here, EGLN2 is linked to hepatocellular carcinoma.