Many candidate targets of TFS shown in Supplementary Table 8 like cytokines (IL-1, IL-6, IL-10 and TNF-α), chemokines (CCL3, CCL5), chemokine receptor (CXCR4), pro-inflammatory mediators (COX-2, LOX-5 and iNOS) and related signaling pathways (NF-κB, Nrf2) participated in CRC progression. Here, IL1B is linked to colorectal carcinoma.