Based on the above microarray data validated by qRT-PCR, 11 prominent genes (SLAMF7, MUC1, CAV3, VTN, IGFBP3, IGFBP5, WISP1, PTGS2, CA9, EDN1, and CYR61) were selected from the four cell biological behaviors identified here, as potential candidate targets of Talin-1 in HCC. The gene discussed is IGFBP5; the disease is hepatocellular carcinoma.