Obesity in mice, similar to humans, decreased arachidonyl-LPE, LPI, and LPS (Figure 6F). High-fat feeding increased arachidonyl-LPA, and CES2 expression reversed obesity-induced alterations in arachidonyl-LPA, LPI, and LPE (Figure 6F). Here, CES2 is linked to obesity due to melanocortin 4 receptor deficiency.