CRP and Sepsis: C-reactive protein (CRP), one of the biomarkers that has been in longer use inpediatric sepsis, is a non-specific, acute-phase protein that increases 4-6hours after exposure to an inflammatory trigger (infectious or not) and has an8-hour doubling time, peaking from 36 to 50 hours after the trigger stimulus.CRP has a 19-hour half-life.