Urinary NGAL wasvalidated as an early biomarker of acute kidney injury in a prospective cohortstudy(54) involving140 children from 1 month to 21 years of age in which acute kidney failure wasgraded using the pRIFLE (Pediatric modified Risk Injury, Failure, Loss,End-stage Kidney Disease) criteria. The gene discussed is LCN2; the disease is acute kidney injury.