Whencohort studies were analyzed, TNF inhibitors were associated with reduced risk ofall cardiovascular events (pooled and adjusted RR 0.46, 95% CI 0.28 to 0.77),myocardial infarction (pooled and adjusted RR 0.81 95% CI 0.68 to 0.96) and stroke(pooled and adjusted RR 0.69, 95% CI 0.53 to 0.89). The gene discussed is TNF; the disease is Stroke.