Proinflammatory cytokines and other factors overproduced in psoriasis contribute tothe increased risk of developing metabolic syndrome (MS) and cardiovascular disease.The activation and expansion of Th-1 and Th-17 cells would be responsible for thehigh production of inflammatory cytokines, especially TNF-alpha, IFN-gamma, IL-1,IL-2, IL-6, IL-8 and IL-17, with effects on several processes, such as angiogenesis,adipogenesis, insulin signaling, lipid metabolism and immune cell traffic. This evidence concerns the gene INS and psoriasis.