However, although TP53 T-to-A transition rs1042522 is reportedly found in60%, it was reported in several malignant tumors, and germline mutations inrs1042522 are thought to be associated with Li–Fraumeni syndrome, which ischaracterized by a hereditary predisposition to several cancers.6,7 Accordingly, this germline SNV may be the pathologic change. The gene discussed is TP53; the disease is cancer.