BTG2 and cancer: B-celltranslocation gene 2 (BTG2) acts as a tumor suppressor gene for a number of cancers andit is stimulated by a p53-dependent pathway, which subsequently leads to the DNA damage.BTG2 gene belongs to an anti-proliferative family protein which hashighly conserved domains of BTG-Box A (Y50–N71) and BTG-Box B (L97–E115) (11, , –14).