Previously, despite the absence of detectable phosphorylation of Y641 on STAT6 in KS tissue [24], we clearly observed there were more nuclear localization of total STAT6 in KS tissues than in normal skin controls (Fig 1A and 1B), which is further verified by the immunofluorescence assays against STAT6 and LANA (Fig 1C and 1D). This evidence concerns the gene STAT6 and Kaposi's sarcoma.