Expression of these proteins and miR-210 has been studied in a variety of tumor types including SCCs of different locations within the upper aero digestive track [35, 36]; however, evidences for the coordinated activation of the HIF-1α/miR-210/ISCU pathway has only been previously reported by our group in paragangliomas [26, 37], a rare benign neuroendocrine neoplasia. This evidence concerns the gene HIF1A and paraganglioma.