Besides the very well-known HIF-1α-driven hyperglycolytic phenotype that produces vast amounts of lactic acid, the activation of the miR-210/ISCU axis likely reduces the mitochondrial electron transport what contributes to the shift from oxidative phosphorylation to glycolytic metabolism that could lead, on one hand, to intracellular acidification of cancer cells and, on the other hand, to the generation of glycolytic intermediates that could be diverted into branched metabolic pathways allowing the generation of biosynthetic precursors required for tumor cell proliferation and invasion. The gene discussed is HIF1A; the disease is cancer.