HPX and neoplasm: When tumor size, nodal metastasis, disease stage and recurrence were introduced in multivariate models to assess whether Hx+-phenotype has an independent prognostic meaning in surgically treated patients that did not received postoperative radiotherapy, statistical significance decreased to p = 0.220 although the trend toward low overall survival persisted (HR: 1.44; 95% CI: 0.796–2.69).