HIF-1α and CAIX are also found co-expressed with MCT4 and MCT1 in some tumor nests but the overlapping was incomplete thus suggesting that the HIF-1α- and MCT1/MCT4-driven metabolic remodeling towards phenotypes consisting in hyperglycolytic cells and a lactate rich microenvironment, respectively, are independently regulated. Here, HIF1A is linked to neoplasm.