As expected, transwell assays demonstrated that the restoration of MAP4K3 expression significantly promoted HCC cell migration and invasiveness initiated by miR-199a-5p and let-7c (Figure 5D and 5E), suggesting that the 3′-UTR region of MAP4K3 is required for the actions of miR-199a-5p and let-7c. Here, MAP4K3 is linked to hepatocellular carcinoma.