MAPK8 and prostate carcinoma: For example, a new ionic Pd(II) complex, [(bipy)Pd(Pcurc)][CF3SO3], with the metal center coordinated to two different chelating ligands, the pure curcumin (Pcurc) and the 4,4′-dinonyl-2,2′-bipyridine (bipy), induces both cell growth inhibition and apoptosis of human prostate cancer cells, (LnCaP, PC3, and DU145) through the production of ROS and JNK phosphorylation associated with GSTp1 down-regulation.