Here, it is demonstrated that the trans-thiosemicarbazone-based, Schiff base palladium (Pd) (II) complex, DMABTSPd(TSPd) (with the bare amino group), could inhibit the cell viabilities, promote the cleavage of PARP, and reduce the expression of PCNA, suggesting that DMABTSPd(TSPd) induces apoptosis in human gastric carcinoma cell lines, BGC823 and SGC7901, consistent with the above studies. Here, PCNA is linked to gastric carcinoma.