Divers mutations in the human FOXP3 gene result in an allotropic syndrome of multi-organ autoimmunity (immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome [17]) and similar effects were observed in the scurfy mouse, a murine model carrying a mutation in Foxp3 [18]. The gene discussed is FOXP3; the disease is polyendocrinopathy.