FANCA and Friedreich ataxia: This study indicated significant accumulation of R-loops in representative genes prone to form R-loops by DNA:RNA immunoprecipitation and quantitative PCR (DRIP-qPCR) in different cell lines, including human FANCA−/− and FANCD2−/− FA patient cells, HeLa cells depleted of FANCD2, and primary bone marrow cells from FANCD2-deficient mice.