For example, the mitochondrial protein TMEM65 is amplified and overexpressed in ~50% of BM from breast and lung cancers, SOX11 is amplified and overexpressed in ~30% of breast and ~80% of lung cancer-BM, and NRG1 is lost and suppressed in ~60% of BCBM [29,32]. This evidence concerns the gene TMEM65 and lung cancer.