During tumor invasion, GBM cells from the tumor migrate towards the neighboring normal tissue by extending their edge actin-rich cancer-specific membrane protrusions forming invadopodia with the ability to infiltrate and degrade physical barriers, such as basement membranes, extracellular matrix (ECM), and cell junctions by metalloproteinases (MMPs) [30,35,36]; podosome/invadopodia are identified for their high expression levels of F-actin and/or cortactin [46]. The gene discussed is CTTN; the disease is glioblastoma.