RAC1 and glioblastoma: Figure 7 is a simplified model of some of the proteins involved in the podosome/invadopodia generation mechanism and a model of the involvement of IQGAP1 in GBM progression based on the present study. Figure 7 also includes IQGAP1 relations with the upstream signaling pathway involving the small GTP-binding proteins Cdc42/Rac1 and Arp2/3-N-WASp interacting complexes [38,47,49].