For instance, EMT induction by PDGF-D represents a mechanism of chemoresistance in prostate cancer cells, where PDGF-D overexpression correlated with the downregulation of E-cadherin and increased expression of Snail2, N-cadherin, ZEB1, ZEB2 and vimentin [142]. The gene discussed is PDGFD; the disease is Familial prostate cancer.