Especially in a variety of ischemia or ischemia-reperfusion (IR) models in vivo and in vitro, for example, inhibition of Drp1 selectively blocks mitophagy without affecting mitochondrial biogenesis, but Drp1-dependent mitophagy is triggered to remove damaged mitochondria during the early phase of ischemic-induced injury [106]. The gene discussed is DNM1L; the disease is ischemia.