Moreover, the therapeutic impact of this gene therapy approach may be further refined by fine‐tuning IFN‐β expression using transcriptional and post‐transcriptional regulation to make transgene expression more specific for tumor cells or tumor microenvironment (Ruan et al., 2001; Wu et al., 2009; Yawata et al., 2011). The gene discussed is IFNB1; the disease is neoplasm.