IFNB1 and glioblastoma: Based on this concept, previously our group has shown that local intracranial delivery of a recombinant adeno‐associated virus (AAV) vector driving expression of human IFN‐β from a neuron‐specific promoter can eliminate orthotopic U87 human glioblastoma in athymic nude mouse model (Maguire et al., 2008).