In the advancement and evaluation of therapeutic strategies for AD pathology, the i.c.v. Aβ1-42-infusion model is a useful complement to transgenic mouse models52, although the mechanisms that underlie many features of AD, including synaptotoxicity, the hyperphosphorylation of tau, apoptosis, and neurodegeneration are still not clearly known. The gene discussed is MAPT; the disease is Alzheimer disease.