These include over 12 exons that were differentially spliced in titin (TTN) in cardiomyopathy samples, including exons 140 and 246, the co-occurring reduced inclusion of exon 6 of the cardiomyopathy associated protein PDZ and LIM domain protein 3 (PDLIM3)33, co-occuring increased inclusion of exon 11 in CD36, and inverse regulation of exon 6 in the tight junction protein claudin domain containing 1 (CLDND1)(AltAnalyze exon notations, Fig. 4A). Here, PDLIM3 is linked to cardiomyopathy.