Furthermore, network analysis of cardiomyopathy-regulated genes identified genes connected among the 14 most commonly regulated genes in our dataset, including secreted frizzled-related protein 4 (SFRP4), hyaluronan and proteoglycan link protein 1 (HAPLN1), alpha tubulin 3e (TUBA3E), SPARC related modular calcium binding 2 (SMOC2), signal transducer and activator of transcription 4 (STAT4), adiponectin CQ (ADIPOQ), thrombospondin 4 (THBS4), thy-1 cell surface antigen (THY1), glycine N-methyltransferase (GNMT), corticotropin releasing hormone binding protein (CRHBP), and MYH6 (Fig. 2A). Here, SMOC2 is linked to cardiomyopathy.