LRRK2 and Parkinson disease: The LRRK2R1441G mutation, which is at the same location as the LRRK2R1441C mutation, is located in the ROC (Ras of complex proteins) domain of the LRRK2 gene7, 8, 9, 10, and is the most common cause of familial PD in the Basque region of Spain11.