In a bleomycin (BLM)-induced pulmonary fibrosis model, miR-497-5p was upregulated, and suppressing miR-497-5p expression using a lentiviral agent in vivo reduced the expression of fibrotic markers Mmp2, Mmp9 and Tgfb1 via enhancing the expression of Reck, suggesting augmented in vivo lung repair. Here, TGFB1 is linked to pulmonary fibrosis.