Development of preeclampsia was not observed to be related with any significant change in the methylation of DMRs of SNRPN, PEG10 and MEST. However, similar to the reverse trend observed in the mRNA levels of these genes in molar villi and JEG-3 cells, a reverse trend was observed in the CpG methylation in these groups. This evidence concerns the gene SNRPN and preeclampsia.