While it is clear that CD8+ T cells are required to regulate the antibody response in TLR7[Tg] lupus-prone mice, more studies will need to be performed to fully elucidate any regulatory mechanism that may be imparted by these brain-resident CD8+ T cells and determine if they are similar in function to memory cells previously described in models of viral or bacterial infection. This evidence concerns the gene CD8A and systemic lupus erythematosus.