TLR7 and systemic lupus erythematosus: We next found that the changes in expression of nine of these twelve adhesion molecules were significantly upregulated on brain-infiltrating CD8+ T cells in TLR7[Tg] lupus-prone mice; namely CD49d, CD11a, CD31, CD54, CD49f, CD29, CD48, and CD43aag (Fig. 3e,f), as well as CD44 (Fig. 2a,b) and CD103 (Fig. 2c,d).