TLR7 and systemic lupus erythematosus: While it is clear that CD8+ T cells are required to regulate the antibody response in TLR7[Tg] lupus-prone mice, more studies will need to be performed to fully elucidate any regulatory mechanism that may be imparted by these brain-resident CD8+ T cells and determine if they are similar in function to memory cells previously described in models of viral or bacterial infection.