We next found that the changes in expression of nine of these twelve adhesion molecules were significantly upregulated on brain-infiltrating CD8+ T cells in TLR7[Tg] lupus-prone mice; namely CD49d, CD11a, CD31, CD54, CD49f, CD29, CD48, and CD43aag (Fig. 3e,f), as well as CD44 (Fig. 2a,b) and CD103 (Fig. 2c,d). This evidence concerns the gene ITGAE and systemic lupus erythematosus.