The study established prominent interactions of NCAM1 with integrins that are modulated by ZIP6, thereby corroborating observations by others, which had previously documented that NCAM1 (i) either associates directly with focal adhesion complexes during EMT in the NMuMG model23, or (ii) induced focal adhesions in a cell-cell contact dependent manner in a human neuroblastoma cell model24. Here, NCAM1 is linked to neuroblastoma.