Consistent with these findings, YAP1 S127A, but not the activated 5SA/S94A mutant incapable of binding TEAD transcription factors, significantly elevated cellular velocity of PC3 and LNCaP prostate cancer cells cultured under static conditions (Fig. 5a–c; Supplementary Fig. 6a). The gene discussed is YAP1; the disease is Familial prostate cancer.