NFKBIE and Familial prostate cancer: By ingenuity pathway analysis, differentially expressed genes were found to encode enzymes and transcription regulators required for anti-apoptotic and proliferative signalling associated with several cancers, including small cell lung, colon, pancreatic, thyroid and prostate cancer (MYC, KRAS, CTNNB1, ABL1, CDKN1B, BAD, NFKB2 and NFKBIE) (Fig. 2a).