We identified two individual's tumours with hypermutator phenotypes (HKNPC-003, HKNPC-033) with 2,051 and 817 somatic mutations in coding regions, respectively (Fig. 2); both tumours harboured mutations of mismatch repair genes, including MSH6 (HKNPC-003) and MLH1 (HKNPC-033). This evidence concerns the gene MLH1 and neoplasm.