NFKB1 and nasopharyngeal carcinoma: In summary, our study of over 100 micro-dissected NPCs using WES, WGS and FISH revealed a higher degree of somatic mutation and structural variation (SV) in NPC than was previously recognized and enabled the discovery of several novel genomic events that facilitate NPC tumorigenesis, principal among these being NF-κB pathway activation in NPCs with low LMP1 expression.