TGFB1 and renal fibrosis: Furthermore, Egr‐1 can directly induce the expression of collagen gene, matrix remodelling factors and fibrogenic cytokines TGF‐β and NF‐κB, while Egr‐1 deficiency alleviates TGF‐β‐ and NF‐κB‐induced renal fibrosis and inflammation in TECs 93.