In addition to hypoxic activation, it worth noting that, other factors also induce fibrogenic effects in CKD via oxygen‐independent activation of HIF‐1 pathway, including, for example, angiotensin II (Ang II), epidermal growth factor, TNF‐1α, interleukin‐1, nitric oxide and reactive oxygen species (ROS) 64. This evidence concerns the gene AGT and chronic kidney disease.