This category was also significantly enriched for heritability of AD (5.5, P = 2.4 × 10−7), in addition to liver (10.5, P = 1.1 × 10−5), and these AD signals remained significant even after the removal of APOE (chr19: 44,905,754–44,909,393) (5.5, P = 2.5 × 10−7 and 10.5, P = 1.1 × 10−5, respectively). Here, APOE is linked to Alzheimer disease.