Moreover, OPN deficient mice are relatively protected against MS [83], RA [84], type 1 diabetes mellitus (T1DM) [85], autoimmune uveitis [86], autoimmune hepatitis [87, 88], intestinal bowel disease (IBD) [89], and Sjögren's syndrome (SS) [90, 91]. This evidence concerns the gene SPP1 and synovial sarcoma.