INS and hydrops fetalis: The increase in VO2 may be related to an EET-mediated alternate metabolic strategy of HF-fed mice, that is, to increase the metabolic rate in response to increased EET-A-mediated PGC-1α expression and mitochondrial function leading to a reprogramming of adipose stem cells to brown-like cells, thus allowing the recovery of homeostatic control and the subsequent decrease in body fat, increase in insulin sensitivity, and normalization of oxygen consumption.