The observed increase was PGC-1α-dependent as the levels of both Mfn1 and Mfn2 in adipose tissue from PGC1α-deficient mice reduced (p < 0.05) as compared to HF diet fed mice treated with EET-A alone (Figures 3(d) and 3(e)). The gene discussed is PPARGC1A; the disease is hydrops fetalis.