The finding that EET-A restored oxygen consumption and respiratory quotient to levels found in lean mice is supported by the beneficial increase in PGC-1α, SIRT1, pAMPK, and COX-IV (a unit of the mitochondrial OXPHOS complex) in the adipose tissue of mice fed a HF diet and treated with EET-A, thus highlighting the role of EETs in mitochondrial energy production and expenditure. Here, COX4I1 is linked to hydrops fetalis.