PPARGC1A and obesity due to melanocortin 4 receptor deficiency: EET-mediated induction of PGC-1α and HO-1 favors an increase in mitochondrial fusion, biogenesis, and OXPHOS, thereby providing metabolic protection in HF diet induced obesity in mice; this finding is supported by recent reports by us and others showing that HO-1 regulates mitochondrial function, quality control, biogenesis, and dynamics [46, 57, 58].