AKT1 and brain injury: Also, puerarin could provide neuroprotection against traumatic brain injury-induced oxidative stress characterized by the severe disturbance of redox balance; puerarin treatment could lead to a significant decrease in the MDA content and increase in the level of GSH in comparison with vehicle treatment after traumatic brain injury, at least in part, through the activation of PI3K-Akt pathway, which may represent a new promising therapeutic agent in the treatment of traumatic brain injury in the future [46].