Hypermethylation or hypomethylation of key genes for the development of depression in men, such as the AR, BDNF, 5HTT, FKBP5, and NR3C1 constitute independent risk and resilience factors for depression, AUDs, and suicidal behavior and further interact with the prior described genetic predisposition. This evidence concerns the gene SLC6A4 and major depressive disorder.