Various clinical studies have reported the efficacy of antioxidant treatment (such as N-acetylcysteine (NAC) and lecithinized superoxide dismutase (PC-SOD)) for IPF (Bando et al., 2010[3]; Behr et al., 2009[6], 2016[5]; Homma et al., 2012[14]; Huang et al., 2015[15]; Kamio et al., 2014[17]; Martinez et al., 2014[20]; Okuda et al., 2016[22]; Raghu et al., 2012[24]; Sakamoto et al., 2013[30], 2015[31]; Tomioka et al., 2005[36]). Here, SOD1 is linked to idiopathic pulmonary fibrosis.