Genazzani et al. (2008[25]) reported that myo-inositol supplementation (2 g/d) plus folic acid (200 μg/ d) was effective in the amelioration of plasma luteinizing hormone (LH), Prolactin (PRL), and testosterone levels in overweight PCOS patient after 12 weeks consumption, probably through the reduction in plasma insulin concentration (Genazzani et al., 2008[25]). This evidence concerns the gene INS and polycystic ovary syndrome.