LEP and obesity due to melanocortin 4 receptor deficiency: Interestingly, this polymorphism has been scanty studied in obesity; when association between serum lipids and LEP/LEPR gene polymorphisms in obese Japanese children was studied, the rs1805134 SNPs showed a significant relationship with serum lipid profile, since lower triglyceride levels were obtained in rs1805134 C/C homozygotes [19].